When minor aches and pains make it difficult to settle down at night, Equate Maximum Strength Pain Relief PM Liquid provides a convenient dual-action formula combining powerful pain relief with a nighttime sleep aid.
Each 30 mL dose contains 1,000 mg of acetaminophen for temporary relief of minor aches and pains, together with 50 mg of diphenhydramine HCl, a nighttime sleep-aid ingredient. This combination is designed for occasional nighttime use when physical discomfort is accompanied by sleeplessness.
With a pleasant Midnight Cherry flavor and an easy-to-measure liquid formula, Equate Pain Relief PM offers a practical alternative to tablets or caplets. A dosage cup is included for accurate measurement.
Dual-Action Nighttime Relief
Equate Pain Relief PM combines two established active ingredients in one maximum-strength nighttime formula:
- Acetaminophen 1,000 mg per 30 mL – pain reliever
- Diphenhydramine HCl 50 mg per 30 mL – nighttime sleep aid
The formula temporarily relieves occasional minor aches and pains when these are accompanied by difficulty sleeping.
Relief When Aches and Pains Disrupt Your Night
Minor headaches, body aches and other everyday discomforts can sometimes make falling asleep more difficult. Equate Pain Relief PM is formulated specifically for nighttime use, providing pain relief while the diphenhydramine component acts as a nighttime sleep aid.
Its liquid format is particularly convenient for adults who prefer not to take tablets or caplets.
Maximum Strength Formula
One adult dose of 30 mL provides:
Acetaminophen – 1,000 mg
Helps provide temporary relief from minor aches and pains.
Diphenhydramine HCl – 50 mg
Acts as a nighttime sleep aid when occasional sleeplessness accompanies minor pain.
Only one 30 mL dose should be taken within a 24-hour period unless otherwise directed by a healthcare professional.
Midnight Cherry Flavored Liquid
The liquid has a Midnight Cherry flavor, making it an easy-to-take alternative to solid tablets and caplets.
The formula contains 10% alcohol and comes supplied with a dosage cup to help ensure the correct amount is measured.
Compare to Vicks® PainQuil® PM Active Ingredients
Equate Maximum Strength Pain Relief PM contains the same types and strengths of active ingredients found in Vicks® PainQuil® PM, providing a convenient store-brand alternative for occasional nighttime pain and sleeplessness.
Vicks® and PainQuil® are registered trademarks of The Procter & Gamble Company. Equate is not affiliated with or endorsed by The Procter & Gamble Company.
Why Choose Equate Pain Relief PM?
- Maximum-strength nighttime formula
- 1,000 mg acetaminophen per 30 mL dose
- 50 mg diphenhydramine HCl per 30 mL dose
- Combines a pain reliever with a nighttime sleep aid
- For temporary relief of occasional minor aches and pains with accompanying sleeplessness
- Fast-acting liquid format
- Midnight Cherry flavor
- Convenient alternative to tablets and caplets
- Dosage cup included
- Gluten-free formula
- Contains 10% alcohol
- Suitable for adults and children aged 12 years and over when used as directed
- 12 fl oz / 355 mL bottle
Directions
Adults and children aged 12 years and over: take 30 mL at bedtime.
Take only one dose in a 24-hour period.
Use only the dosage cup supplied with the product.
Children under 12 years: do not use.
Always follow the complete directions and warnings printed on the product packaging.
Important Safety Information
This product contains acetaminophen. Severe liver damage may occur if more than the recommended amount is taken, if it is taken with other medicines containing acetaminophen, or in certain circumstances involving regular alcohol consumption.
Do not use with any other medicine containing acetaminophen.
Because the product also contains diphenhydramine, do not use it with another medicine containing diphenhydramine, including products applied to the skin.
Marked drowsiness may occur. Avoid alcoholic drinks and use caution when driving or operating machinery.
Speak with a doctor or pharmacist before use if you are taking other medicines, have an existing medical condition, are pregnant or breastfeeding, or are unsure whether this product is suitable for you.
If sleeplessness persists continuously for more than two weeks, seek medical advice, as persistent insomnia can be a symptom of an underlying medical condition.
Product Details
Brand: Equate
Product: Maximum Strength Pain Relief PM
Format: Oral Liquid
Flavor: Midnight Cherry
Bottle Size: 12 fl oz / 355 mL
Active Ingredients per 30 mL: Acetaminophen 1,000 mg / Diphenhydramine HCl 50 mg
Purpose: Pain Reliever / Nighttime Sleep Aid
Alcohol Content: 10%
Recommended Age: 12 years and over
Dosage: 30 mL at bedtime, maximum one dose per 24 hours
Dosage Cup: Included
Please Note
Product packaging, appearance and formulation may occasionally be updated by the manufacturer. Always refer to the product label received for the most current ingredients, directions, warnings and other information.

